Analysis of allergic reactions from chicken embryo cell vaccines in patients with food allergy to egg proteins
DOI:
https://doi.org/10.60108/ce.175Keywords:
influenza vaccines; triple viral vaccine; egg allergyAbstract
Introduction. Allergy to egg proteins is common in pediatric populations. Some vaccines are prepared from chicken embryonic fibroblasts and in chicken embryonic eggs, which can cause allergic reactions in such patients.
Objective. The main objective of this review is to evaluate the safety of inactivated chicken embryo cell vaccines administered to patients with food allergy to egg proteins.
Methods. The bibliographic search has been carried out using articles published between 2005 and 2020 of the following databases: Cochrane, PubMed and Google Academic
Results. Most doses given do not present reactions, being mild. An allergological study is performed in patients with previous reactions or persistent asthma. Fear of an adverse drug reaction leads to delays in delivery. Gelatins, antibiotics and other excipients are the etiology of most allergic reactions.
Conclusion. Immunization with these vaccines should not be postponed or contraindicated in patients allergic to the egg since there is no increased risk of allergic reaction, being most cases due to other components. Vaccination in allergy service will be carried out in cases of previous severe reaction or persistent asthma.
References
Poland GA, Ovsyannikova IG, Crooke SN, Kennedy RB. SARS-CoV-2 Vaccine Development: Current Status. Mayo Clin Proc. 2020;95(10):2172-2188.
Echeverría Zudaire L, Ortigosa del Castillo L, Alonso Lebreros E, Álvarez García FJ, Cortés Álvarez N, García Sánchez N et al. Documento de consenso sobre la actitud ante un niño con una reacción alérgica tras la vacunación o alergia a sus componentes vacunales. An Pediatr (Bar). 2015;83(1):63.e1-63.e10
Li X, Mukandavire C, Cucunubá ZM, Echeverria Londono S, Abbas K, Clapham HE et al. Estimating the health impact of vaccination against ten pathogens in 98 low-income and middle-income countries from 2000 to 2030: a modelling study. Lancet. 2021 Jan 30;397(10272):398-408. doi: 10.1016/S0140-6736(20)32657-X. Erratum in: Lancet. 2021 Feb 20;397(10275):670.
Calendario de vacunaciones AEP 2021. URL disponible en: https://vacunasaep.org/profesionales/calendario-de-vacunaciones-de-la-aep-2021
Dreskin SC, Halsey NA, Kelso JM, Wood RA, Hummell DS, Edwards KM et al. International Consensus (ICON): allergic reactions to vaccines. World Allergy Organ J. 2016 Sep 16;9(1):32.
Herman JJ, Radin R, Schneiderman R. Allergic reactions to measles (rubeola) vaccine in patients hypersensitive to egg protein. J Pediatr. 1983;102(2):196-9.
O'Brien TC, Maloney CJ, Tauraso NM. Quantitation of residual host protein inchicken embryo-derived vaccines by radial immunodiffusion. ApplMicrobiol. 1971;21(4):780-2.
Fasano MB, Wood RA, Cooke SK, Sampson HA. Egg hypersensitivity and adverse reactions to measles, mumps, and rubella vaccine. J Pediatr.1992;120(6):878–81.
Aickin R, Hill D, Kemp A. Measles immunisation in children with allergy to egg. BMJ. 1994;309:223-5.
Freigang B, Jadavji TP, Freigang DW. Lack of adverse reactions to measles, mumps, and rubella vaccine in egg-allergic children. Ann Allergy. 1994;73:486-8.
Cerecedo Carballo I, Dieguez Pastor MC, Bartolomé Zavala B, Sánchez Cano M, de la Hoz Caballer B. Safety of measles-mumps-rubella vaccine (MMR) in patients allergic to eggs. Allergol Immunopathol (Madr). 2007 May-Jun;35(3):105-9.
Prevalence of Anti-Gelatin IgE Antibodies in People With Anaphylaxis After Measles-Mumps-Rubella Vaccine in the United States. Pediatrics. 2002: e71. Disponible en: http://www.pediatrics.org/cgi/content/full/110/6/e71
Kelso JM, Jones RT, Yunginger JW. Anaphylaxis to measles, mumps, and rubella vaccine mediated by IgE to gelatin. J Allergy Clin Immunol. 1993 Apr;91(4):867-72
Sakaguchi M, Yoshida T, Asahi T, Aoki T, Miyatani Y, Inouye S. Development of IgE antibody to gelatin in children with systemic immediate-type reactions to vaccines. J Allergy Clin Immunol. 1997 May;99(5):720-1.
Ficha técnica de vacunas. Comité Asesor de Vacunas de la Asociación Española de Pediatría. URL disponible en: https://vacunasaep.org/profesionales/fichas-tecnicas-vacunas/resultados?diseases=157
Taylor SL. Food allergies. Food Tecnology 1986;39:98-105.
Kilshaw PJ, Cant AJ. The passage of maternal dietary proteins into human breast milk. International Archives of Allergy and Applied Immunology, 1984;75:8-15.
Eggesbo M, Botten G, Halvorsen R, Magnus P. The prevalence of allergy to egg: a population-based study in young children. Allergy. 2001; 56: 403-11.
Osterballe M, Hansen TK, Mortz CG, Host A, Bindslev-Jensen C .The prevalence of food hypersensitivity in an unselected population of children and adults. Pediatr Allergy Immunol. 2005;16: 567–73.
Chen J, Hu Y, Allen KJ, HoMHK, Li H. The prevalence of food allergy in infants in Chongqing, China. Pediatr Allergy Immunol. 2011; 22: 356-60.
Vesikari T, Sadzot-Delvaux C, Rentier B, Gershon A. Increasing coverage and efficiency of measles, mumps, and rubella vaccine and introducing universal varicella vaccination in Europe: a role for the combined vaccine. Pediatr Infect Dis J. 2007 Jul;26(7):632-8.
Marin M, Broder KR, Temte JL, Snider DE, Seward JF; Centers for Disease Control and Prevention (CDC). Use of combination measles, mumps, rubella, and varicella vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2010 May 7;59(RR-3):1-12.
Varicella and herpes zoster vaccines: WHO position paper, June 2014. Wkly Epidemiol Rec. 2014;89(25):265-87.
Barış HE, Boran P, Kıykım A, Barış S, Özen A, Karakoç Aydıner E. Immunization practices in children with a history of allergies. Turk Pediatri Ars 2020; 55(3):244–50
Sánchez J, Ramírez R, Cardona R. Frecuencia de las reacciones alérgicas a la vacuna triple viral en pacientes con alergia al huevo. Biomédica 2018;38:514-520.
Tan MS, Teoh EJ, Hor CP, Yeoh AA. Measles-Mumps-Rubella vaccine for children with egg allergy: Is admission for inpatient vaccination necessary? Med J Malaysia. 2016 Aug;71(4):157-160.
Nagao M, Fujisawa T, Ihara T, Kino Y. Highly increased levels of IgE antibodies to vaccine components in children with influenza vaccine–associated anaphylaxis. J Allergy Clin Immunol 2016;137:861-7.
Turner PJ, Southern J, Andrews NJ, Miller E, Erlewyn-Lajeunesse M; SNIFFLE-2 Study Investigators. Safety of live attenuated influenza vaccine in young people with egg allergy: multicentre prospective cohort study. BMJ. 2015 Dec 8;351:h6291. doi: 10.1136/bmj.h6291.
Martínez Checa M.I, Verdugo Blanquero G, Marchena Rubio R. La vacuna triple vírica en alérgicos al huevo, como práctica segura en atención primaria. 2015. Disponible en: http://congresoenfermeria.es/libros/2016/sala3/6097.pdf
Pérez-Vilar S, Gutiérrez-Gimeno M.V, Rodríguez-Galán M.A., Díez-Domingo J, Puig-Barberà J, Gomar-Fayos J, Alguacil-Ramos A.M. Sospecha de reacciones adversas a la vacuna triple vírica notificadas al Centro de Farmacovigilancia de la Comunidad Valenciana. 2013. DOI: 10.1016/j.anpedi.2012.07.013
Greenhawt MJ, Spergel JM, Rank MA, Green TD, Mansoor D, Sharma H et al. Safe administration of the seasonal trivalent influenza vaccine to children with severe egg allergy. Ann Allergy Asthma Immunol. 2012 Dec;109(6):426-30. doi: 10.1016/j.anai.2012.09.011. Epub 2012 Oct 24. Erratum in: Ann Allergy Asthma Immunol. 2013 Apr;110(4):309. Sinh, Divya [corrected to Parikh, Divya Sinha]. Erratum in: Ann Allergy Asthma Immunol. 2013 Dec;111(6):580.
Webb L, Petersen M, Boden S, LaBelle V, Bird JA, Howell D, Burks AW, Laubach S. Single-dose influenza vaccination of patients with egg allergy in a multicenter study. J Allergy Clin Immunol. 2011 Jul;128(1):218-9. doi: 10.1016/j.jaci.2011.02.013.
Comité Asesor de Vacunas de la Comunidad de Madrid. Evaluación del protocolo de vacunación en alérgicos al huevo con vacuna triple vírica. Julio, 2011. Disponible en: http://www.ampap.es/wp-content/uploads/2015/01/2011_07_Alergicos_huevo_TV_CAV-Madrid.pdf
Chung EY, Huang L, Schneider L. Safety of Influenza Vaccine Administration in Egg-Allergic Patients. Pediatrics May 2010, 125 (5) e1024-e1030; DOI: https://doi.org/10.1542/peds.2009-2512
Fina Avilés F, Campins Martí M, Martínez Gómez X, Rodrigo Pendás JA, Lushchenkova O, Pimós Tella L et al. Vacuna triple vírica y alergia al huevo. Experiencia en una unidad de vacunación hospitalaria [MMR vaccine and egg allergy. Experience in a hospital immunization unit]. An Pediatr (Barc). 2007 Oct;67(4):362-7. Spanish. doi: 10.1016/s1695-4033(07)70654-9.
Sánchez J.L, Seara Aguilar G, Ansede Cascudo J.C, García Sánchez E, De la Calzada E, Martínez Gimeno A, Cameno Heras M, Martín- Carillo Domínguez P, Esteban Niveiro M.J, Barranco Ordóñez D. Protocolo de vacunación con triple vírica en niños alérgicos al huevo. 2007. Disponible en: http://www.ampap.es/wp-content/uploads/2015/01/2007_Protocolo_TV_alergicos_al_huevo.pdf
Torres Borrego J, Guzmán EG. Seguridad de la vacunación triple vírica en pacientes con alergia al huevo [Safety of MMR immunization in egg-allergic children]. An Pediatr (Barc). 2006 May;64(5):464-7.
Downloads
Published
How to Cite
Issue
Section
License
En caso de que el artículo sea publicado, los autores aceptan transferir todos los derechos del trabajo presentado, incluidos los derechos de autor y aquellos relativos a la transmisión electrónica, exclusivamente a CODEM, de manera universal, en todos los idiomas, una vez que el trabajo haya sido aceptado para su publicación dentro de la revista electrónica CONOCIMIENTO ENFERMERO.
El autor podrá hacer copias ilimitadas del trabajo para uso docente, reutilizarlo en su totalidad o parcialmente en un libro escrito por el autor o hacer copias para su distribución en la institución en la que trabaja. CODEM hará mención al nombre del autor en las publicaciones que se realicen del trabajo.
